Mechanistic Insights into the Analgesic Action of Acetaminophen: Its Bioactive Metabolite Induces Peripheral Analgesia in Addition to Central Analgesia.

Hironori Tsuchiya, Yoshiaki Takai, Maki Mizogami

The molecular target and detailed mechanism of analgesic acetaminophen are still not fully understood despite being commonly used for many years. Through a literature search, the present study aimed to characterize the cyclooxygenase inhibitory properties of acetaminophen in comparison with non-steroidal anti-inflammatory drugs and to gain novel mechanistic insights into its analgesic action, especially focusing o…