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Research Article 2016CC0CC0 allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model.

Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelkow, Eva-Maria Mandelkow

Background A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The mutation A152TMAPT was recently identified in patients diagnosed with frontotemporal spectrum disorders, including Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), Corticobasa…

Molecular Neurodegeneration Europe PMC↗

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