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Research Article 2021CC BYFree full text

Sexual Dimorphisms and Asymmetries of the Thalamo-Cortical Pathways and Subcortical Grey Matter of Term Born Healthy Neonates: An Investigation with Diffusion Tensor MRI.

Fadoua Saadani-Makki, Ardalan Aarabi, Mahshid Fouladivanda, Karman Kazemi, Malek Makki, Panagiotis Papanagiotou

Diffusion-tensor-MRI was performed on 28 term born neonates. For each hemisphere, we quantified separately the axial and the radial diffusion (AD, RD), the apparent diffusion coefficient (ADC) and the fractional anisotropy (FA) of the thalamo-cortical pathway (THC) and four structures: thalamus (TH), putamen (PT), caudate nucleus (CN) and globus-pallidus (GP). There was no significant difference between boys and g…

Diagnostics Europe PMC

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Research Article 2020CC BYFree full text

Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.

Wei Xu, Hongchun Li, Liang Wang, Jiamei Zhang, Chunqi Liu, Xuemei Wan +9 more

The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG) signaling in the dorsal striatum (caudate nucleus and putamen, CPu) of mice. Elevated 2-AG in the CPu is essential for the psychostimulant and reinforcing effects o…

Nature Communications Europe PMC

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