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Research Article 2018CC0Free full text

Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial.

Martin Kaczocha, Syed Azim, James Nicholson, Mario J. Rebecchi, Yong Lu, Tian Feng +6 more

Background The primary goal of this study was to determine whether administration of intrathecal morphine reduces postoperative pain. The secondary goal was to determine the effect of intrathecal morphine upon circulating levels of the weakly analgesic endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and the related lipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Methods Forty…

BMC Anesthesiology Europe PMC

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Research Article 2015CC BYFree full text

Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis.

James Nicholson, Syed Azim, Mario J. Rebecchi, William Galbavy, Tian Feng, Ruth Reinsel +4 more

Background There is compelling evidence in humans that peripheral endocannabinoid signaling is disrupted in obesity. However, little is known about the corresponding central signaling. Here, we have investigated the relationship between gender, leptin, body mass index (BMI) and levels of the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in the serum and cerebrospinal fluid (CSF) of primarily…

PLoS ONE Europe PMC

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