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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
8 articles
Newest firstHealthcare systems must balance rising costs with the delivery of effective care, yet the factors underlying large inter-individual differences in healthcare expenditure remain incompletely understood. Here we examine how genome-wide genetic variation contributes to healthcare costs, analysing inpatient, outpatient, primary care and prescription drug expenditure in up to 1,429,889 individuals from 11 studies acros…
Open article record in new tab ↗BackgroundEarly onset obesity in children, almost always accompanied by significant health complications, may be driven by rare genetic variants that influence appetite, metabolism, and nutrient absorption. Traditional treatment approaches are usually insufficient for those with monogenic obesity of this type. Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, and related drugs such as melanoc…
Open article record in new tab ↗BACKGROUNDAlzheimers disease and other dementias are progressive neurodegenerative disorders with profound impacts on cognitive function. There is a shortage of economic evidence relating to the impact Alzheimers disease on healthcare costs and quality-adjusted life-years (QALYs). METHODSWe employed two study designs to model the association between Alzheimers disease and healthcare costs and QALYs. We first estim…
Open article record in new tab ↗BackgroundObservational studies indicated a decreased risk of prostate cancer by SGLT2 inhibitors, but high-quality evidence is lacking to make a clear conclusion. We evaluated the effect of SGLT2 inhibition on prostate cancer risk by triangulating evidence from three methods. MethodsGenetic variants associated with HbA1c levels (P<5x10-8) in the genomic region of the target gene, SLC5A2, were used to proxy SGLT2…
Open article record in new tab ↗BackgroundA critical step in evaluating healthcare interventions is to understand their impact on healthcare costs. However, there is a limited understanding of the causal impact that biomarkers and risk factors for disease have on healthcare-related costs. Previous studies based on observational data have major limitations including residual confounding and reverse causation. Here, we used a genetically-informed…
Open article record in new tab ↗Knowledge of the impact of smoking on healthcare costs is important for establishing the external effects of smoking and for evaluating policies intended to modify this behavior. Conventional analysis of this association is difficult because of omitted variable bias, reverse causality, and measurement error. We approached these challenges using a Mendelian Randomization study design, in which genetic variants asso…
Open article record in new tab ↗Estimates of the marginal effect of measures of adiposity such as body mass index (BMI) on healthcare costs are important for the formulation and evaluation of policies targeting adverse weight profiles. Many existing estimates of this association are affected by endogeneity bias caused by simultaneity, measurement error and omitted variables. The contribution of this study is to avoid this bias by using a novel i…
Open article record in new tab ↗BackgroundHigh adiposity is associated with higher risks for a variety of adverse health outcomes, including higher rates of age-adjusted mortality and increased morbidity. This has important implications for the management of healthcare systems, since the endocrinal, cardiometabolic and other changes associated with increased adiposity may be associated with substantial healthcare costs.\n\nMethodsWe studied the…
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