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Research Article 2023CC BY-NCFree full text · non-commercial reuse

Absorbance-Transmittance Excitation Emission Matrix Method for Quantification of Major Cannabinoids and Corresponding Acids: A Rapid Alternative to Chromatography for Rapid Chemotype Discrimination of Cannabis sativa Varieties.

Adam M. Gilmore, Mostafa A. Elhendawy, Mohamed M. Radwan, Linda H. Kidder, Amira S. Wanas, Murrell Godfrey +3 more

Background: Phytocannabinoids naturally occur in the cannabis plant (Cannabis sativa), and Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) predominate. There is a need for rapid inexpensive methods to quantify total THC (for statutory definition) and THC-CBD ratio (for classification into three chemotypes). This study explores the capabilities of a spectroscopic technique that combines ultraviolet-visible and…

Cannabis and Cannabinoid Research PubMed Central Open Access

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Research Article 2023CC BYFree full text

In Vitro and In Silico Studies of Neolignans from Magnolia grandiflora L. Seeds against Human Cannabinoids and Opioid Receptors.

Pankaj Pandey, Mallika Kumarihamy, Krishna Chaturvedi, Mohamed A. M. Ibrahim, Janet A. Lambert, Murrell Godfrey +2 more

Magnolia grandiflora L. (Magnoliaceae) is a plant of considerable medicinal significance; its flowers and seeds have been used in various traditional remedies. Radioligand binding assays of n-hexane seeds extract showed displacement of radioligand for cannabinoid (CB1 and CB2) and opioid δ (delta), κ (kappa), and µ (mu) receptors. Bioactivity-guided fractionation afforded 4-O-methylhonokiol (1), magnolol (2), and…

Molecules Europe PMC