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Research Article 2025CC BYFree full text

Effect of Central Injection of Anandamide on LPS-Dependent Suppression of GnRH/LH Secretion in Ewes During the Follicular Phase of the Estrous Cycle.

Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Monika Tomczyk, Joanna Bochenek, Andrzej P. Herman

The study investigated the effects of intracerebroventricular (ICV) administration of the endocannabinoid anandamide (AEA) on suppression of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) secretion during lipopolysaccharide (LPS)-induced inflammation in ewes at the follicular phase of the estrous cycle. Animals were divided into three groups: control, LPS (intravenous, IV; 400 ng/kg), and LPS + AEA…

International Journal of Molecular Sciences Europe PMC

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Research Article 2021CC BYFree full text

Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation.

Monika Tomczyk, Dorota Tomaszewska-Zaremba, Joanna Bochenek, Anna Herman, Andrzej P. Herman

This study evaluated the effect of anandamide (AEA) on interleukin (IL)-1β synthesis and gene expression of IL-1β, its type I (IL-1R1) and II (IL-1R2) receptors, and IL-1 receptor antagonist (IL-1RN) in the hypothalamic structures, involved in the central control of reproduction, during inflammation. Animals were intravenously (i.v.) injected with bacterial endotoxin-lipopolysaccharide (LPS) (400 ng/kg) or saline,…

Animals : an Open Access Journal from MDPI Europe PMC

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