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Research Article 2026CC BYFree full text

Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum.

Selen Dirik, Michelle R. Doyle, Courtney P. Wood, Paola Campo, Angelica R. Martinez, McKenzie Fannon +14 more

Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments. Cannabidiol (CBD), a non-psychotropic constituent of cannabis, shows promise in modulating addictive behaviors. This study investigated the effects of chronic CBD administration on alcohol dependence, withdrawal symptoms, and neurodegeneration using two complementary rodent models: chronic intermittent ethanol (CI…

Neuropsychopharmacology Europe PMC

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Research Article 2018CC BYFree full text

Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood.

Jenni Kononoff, Philippe A. Melas, Marsida Kallupi, Giordano de Guglielmo, Adam Kimbrough, Maria Scherma +4 more

Cannabis use is typically initiated during adolescence and is a significant risk factor for the development of cocaine use in adulthood. However, no preclinical studies have examined the effects of adolescent cannabinoid exposure on cocaine dependence in adulthood using the escalation model of cocaine self-administration and the assessment of negative emotional states. In the present study, we found that exposure…

Scientific Reports PubMed Central Open Access

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