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Research Article 2026-02-15CC BYFree full text

Predicting Salmonella Typhi incidence using prevalence metrics from sentinel studies of community-onset bloodstream infections

Nienke N. Hagedoorn, Shruti Murthy, Christian S. Marchello, Jonathan Williman, Faisal Ahmmed, Jason R. Andrews +30 more

BackgroundTyphoid fever incidence estimates are central to policy decisions on vaccine introduction and investments in non-vaccine prevention and control but are often unavailable. We explored whether prevalence metrics from sentinel studies of community-onset bloodstream infections could accurately predict local Salmonella Typhi (S. Typhi) incidence. MethodsUsing a previous systematic review (January 2018-Decembe…

medRxiv medRxiv

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Research Article 2019-02-26CC BYFree full text

Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from south and southeast Asia.

Kelly L Wyres, To N T Nguyen, Margaret M C Lam, Louise M Judd, Nguyen van Vinh Chau, David A B Dance +14 more

BackgroundK. pneumoniae is a leading cause of blood stream infection (BSI). Strains producing extended spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatment and prevention strategies are urgently required, due to severely limited therapeutic options. South and Southeast Asia are major hubs for antimicrobial resistant (AMR) K. pneumoniae, and also for th…

bioRxiv bioRxiv

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