Effect of Fenfluramine on convulsive seizures and rescue medication usage: A case series of adults within the Lennox-Gastaut syndrome spectrum

Lisa Chilson, Boubker Zaaimi, Shanika Samarasekera

IntroductionAdults with Developmental and epileptic encephalopathies (DEE) within the Lennox-Gastaut Syndrome (LGS) spectrum suffer disabling convulsive seizures which may remain refractory and are associated with increased risk of hospitalisations and death. Fenfluramine (FFA) was licenced in the UK for seizures associated with LGS in March 2025.MethodsAdjunctive FFA was assessed in a series of 6 adults with a ge…