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Research Article 2024CC BYFree full text

Feature-Based Molecular Network-Assisted Cannabinoid and Flavonoid Profiling of Cannabis sativa Leaves and Their Antioxidant Properties

Ling Chen, Hong-Ling Li, Hong-Juan Zhou, Guan-Zhong Zhang, Ying Zhang, You-Mei Wang +4 more

Antioxidants Europe PMC

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Research Article 2017CC BYFree full text

MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors.

Tingting Zhang, Tingting Chen, Peipei Chen, Baofeng Zhang, Juan Hong, Ling Chen

Anxiety disorders commonly occur in Parkinson's disease. Using field potential recording and patch-clamp recording, we evaluated influence of MPTP-reduced dopaminergic afferent in basolateral amygdala (BLA), a main region for affective regulation, on excitatory-inhibitory circuits and synaptic plasticity. Field excitatory post-synaptic potential (fEPSP) slopes at external capsule-BLA synapses were increased in MPT…

Frontiers in Molecular Neuroscience Europe PMC

Research Article 2015CC BYFree full text

Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells.

Ling Chen, Long Li, Junde Chen, Lei Li, Zihan Zheng, Jie Ren +1 more

Oleoylethanolamide (OEA), an endocannabinoid-like molecule, was revealed to modulate lipid metabolism through a peroxisome proliferator-activated receptor-α (PPAR-α) mediated mechanism. In present study, we further investigated the activities and mechanisms of OEA in ameliorating hepatic fibrosis in Sv/129 mice induced by a methionine choline-deficient (MCD) diet or thioacetamide (TAA) treatment. Liver fibrosis de…

Oncotarget Europe PMC

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