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Research Article 2024CC BYFree full text

A Novel Non-Psychoactive Fatty Acid from a Marine Snail, Conus inscriptus, Signals Cannabinoid Receptor 1 (CB1) to Accumulate Apoptotic C16:0 and C18:0 Ceramides in Teratocarcinoma Cell Line PA1.

Christina Sathyanathan Vijayaraghavan, Lakshmi Sundaram Raman, Shanmugapriya Surenderan, Harpreet Kaur, Mohanapriya Dandapani Chinambedu, Sadras Panchatcharam Thyagarajan +2 more

The cannabinoid-type I (CB1) receptor functions as a double-edged sword to decide cell fate: apoptosis/survival. Elevated CB1 receptor expression is shown to cause acute ceramide accumulation to meet the energy requirements of fast-growing cancers. However, the flip side of continual CB1 activation is the initiation of a second ceramide peak that leads to cell death. In this study, we used ovarian cancer cells, PA…

Molecules Europe PMC

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Research Article 2021CC BYFree full text

3-Hydroxypropane-1,2-Diyl Dipalmitoleate-A Natural Compound with Dual Roles (CB1 Agonist/FAAH1 Blocker) in Inhibiting Ovarian Cancer Cell Line.

Christina Vijayaraghavan Sathynathan, Lakshmi Sundaram Raman, Sivamurugan Vajiravelu, Thirumal D Kumar, Thyagarajan Sadras Panchatcharam, Gopinathan Narasimhan +3 more

Though it was once known that upregulated Cannabinoid Receptor (CB1) and downregulated Fatty Acid Amide Hydrolase (FAAH1) are associated with tumour aggressiveness and metastasis, it is now clear that upregulated CB1 levels more than a certain point cause accumulation of ceramide and directs cells to apoptosis. Hence, CB1 analogues/FAAH1 blockers are explored widely as anticancer drugs. There are reports on CB1-ag…