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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
4 articles
Newest firstIntroductionThe combination of patient illness and staff absence driven by seasonal viruses culminates in annual "winter pressures" on UK healthcare systems and has been exacerbated by COVID-19. In winter 2022/23 we ran a pilot study aiming to introduce multiplex testing to determine the incidence and burden of SARS-CoV-2, influenza and respiratory syncytial virus (RSV) in our cohort of UK healthcare workers (HCWs…
Open article record in new tab ↗ObjectiveTo estimate the protection of COVID-19 vaccine boosters against mild/asymptomatic and moderate SARS-CoV-2 infection over a 6-month period of XBB.1.5 and JN.1 variant circulation. DesignMulti-state model applied to cohort study, adjusted for vaccination, prior infection, and demographic covariates. SettingNational Health Services (NHS) hospitals in the UK. ParticipantsHealthcare worker cohort including 2,8…
Open article record in new tab ↗BackgroundIn 2022, with high early winter respiratory virus circulation, SIREN, a prospective healthcare worker cohort study monitoring SARS-CoV-2, ran a pilot study introducing multiplex PCR testing for SARS-CoV-2, influenza A/B, and RSV to investigate winter pressures. Three pathways were trialled: (A) on-site swabbing with local laboratory testing, (B) on-site swabbing with UKHSA-commissioned laboratory testing…
Open article record in new tab ↗BackgroundThe protection of fourth dose mRNA vaccination against SARS-CoV-2 is relevant to current global policy decisions regarding ongoing booster roll-out. We estimate the effect of fourth dose vaccination, prior infection, and duration of PCR positivity in a highly-vaccinated and largely prior-COVID-19 infected cohort of UK healthcare workers. MethodsParticipants underwent fortnightly PCR and regular antibody…
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