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Research Article 2025-08-25CC0Free full text

Increasing Value in the Veterans Affairs Healthcare System (VA) with Precision Health: A Continuing Landmark Collaboration with the Department of Energy

Amy C. Justice, Benjamin McMahon, Daniel A. Jacobson, Kelly Cho, Anuj J. Kapadia, Samuel Aguayo +19 more

ObjectiveBy personalizing healthcare to an individuals specific requirements, precision health promises to maximize benefit and minimize harm, thereby maximizing value. We describe here, how in Phase 2 of the Million Veteran Program-Computational Health Analytics for Medical Precision to Improve Outcomes Now (MVP-CHAMPION), artificial intelligence (AI) and high performance computing (HPC) have been applied to Vete…

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Research Article 2024-02-27CC BYFree full text

A Cost-effectiveness analysis of Nivolumab plus chemotherapy for the first-line treatment of locally advanced or metastatic gastric/GEJ/oesophageal adenocarcinoma in the United States of America

Jin Zhou, Yukai Tang, Geli Li

BackgroundNivolumab in combination with chemotherapy significantly improves survival in patients with gastric/gastroesophageal junction (G/GEJ)/esophageal adenocarcinoma.The purpose of this study was to evaluate the cost-effectiveness of Nivolumab plus chemotherapy for G/GEJ/esophageal adenocarcinoma. MethodsA Markov model was developed on the basis of the US healthcare payers perspectives. We estimated the costs…

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