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Research Article 2025CC BYFree full text

Endocannabinoids Block Headache and Anxiety Comorbidity via Two-Pronged Anterior Insular Projections.

Jiang Bian, Yue-Hui Zhang, Li Yin, Jian-Feng Li, Xia Zhang, Xu-Feng Xu

The mechanism of and effective treatment for the headache, with the global prevalence of 52%, and its common anxiety comorbidity remain elusive. Here, we found that chronic isosorbide dinitrate (ISDN) injections induce c-fos expression in the anterior insula (AI), prelimbic cortex (PrL), and oval nucleus of the bed nucleus of the stria terminalis (ovBNST), suggesting their contributions to headache and anxiety com…

Research Europe PMC

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Research Article 2023-02-23CC BYFree full text

Excess burden of respiratory and abdominal conditions following COVID-19 infections during the ancestral and Delta variant periods in the United States: An EHR-based cohort study from the RECOVER Program

Jay K. Varma, Chengxi Zang, Thomas W. Carton, Jason P. Block, Dhruv J. Khullar, Yongkang Zhang +13 more

ImportanceThe frequency and characteristics of post-acute sequelae of SARS-CoV-2 infection (PASC) may vary by SARS-CoV-2 variant. ObjectiveTo characterize PASC-related conditions among individuals likely infected by the ancestral strain in 2020 and individuals likely infected by the Delta variant in 2021. DesignRetrospective cohort study of electronic medical record data for approximately 27 million patients from…

medRxiv medRxiv

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