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Research Article 2025-04-04CC0Free full text

Assessment of Nirmatrelvir-Ritonavir Effects on Acute and Post-Acute COVID-19 Illness in US Adolescents: Target Trial Emulation

Yishan Shen, Bingyu Zhang, Ravi Jhaveri, Jiayi Tong, Ting Zhou, Jiajie Chen +22 more

IMPORTANCENirmatrelvir-ritonavir, an efficacious treatment for acute COVID-19, has yielded conflicting evidence regarding its effectiveness in preventing Long COVID among adults. The effectiveness of nirmatrelvir-ritonavir in adolescents in real-world settings is not well understood. OBJECTIVETo evaluate the effectiveness of nirmatrelvir-ritonavir in adolescents aged 12 to 20 years given within the first five days…

medRxiv medRxiv

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Research Article 2023-02-23CC BYFree full text

Excess burden of respiratory and abdominal conditions following COVID-19 infections during the ancestral and Delta variant periods in the United States: An EHR-based cohort study from the RECOVER Program

Jay K. Varma, Chengxi Zang, Thomas W. Carton, Jason P. Block, Dhruv J. Khullar, Yongkang Zhang +13 more

ImportanceThe frequency and characteristics of post-acute sequelae of SARS-CoV-2 infection (PASC) may vary by SARS-CoV-2 variant. ObjectiveTo characterize PASC-related conditions among individuals likely infected by the ancestral strain in 2020 and individuals likely infected by the Delta variant in 2021. DesignRetrospective cohort study of electronic medical record data for approximately 27 million patients from…

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