Gut microbial and metabolomic alterations associated with herpetic trigeminal neuralgia: an exploratory multi-omics study

Mingyue Tian, Yangyang Wang, Cong Li, Jiaming Fan, Qing Chen, Huilian Bu +2 more

Background: Herpetic trigeminal neuralgia (HTN) is a neuropathic pain disorder caused by varicella-zoster virus invasion of the trigeminal nerve, but its mechanisms remain poorly elucidated. Accumulating evidence implicates gut microbiota dysbiosis and metabolic perturbations in modulating chronic pain via the gut–brain axis, yet their roles in HTN have not been systematically explored. Methods: Integrated multi-o…