The endocannabinoid signaling system in acute and chronic pancreatitis

Alex Mabou Tagne, Jene Jamarillo, Lance R. McMahon, Daniele Piomelli

The endocannabinoid system (ECS) is a ubiquitous lipid signaling network that regulates tissue homeostasis. Increasing evidence indicates that the ECS undergoes profound remodeling during pancreatic injury and may influence key pathological processes underlying acute pancreatitis (AP) and chronic pancreatitis (CP). Interest in this field has grown in parallel with increasing cannabis use among individuals with pan…