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19172026

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Author: Helen C Turner

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Research Article 2019CC BY-NCCC BY-NC allows this article to remain publicly readable here. Reuse is limited to non-commercial use and the recorded source terms.Free full text · non-commercial reuse

"TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure".

Jaime S Horton, Takuya Shiraishi, Naghum Alfulaij, Andrea L Small-Howard, Helen C Turner, Tatsuki Kurokawa +2 more

Activation of the atrial natriuretic signaling pathway is intrinsic to the pathological responses associated with a range of cardiovascular diseases that stress the heart, especially those involved in sustained cardiac pressure overload which induces hypertrophy and the pathological remodeling that frequently leads to heart failure. We identify transient receptor potential cation channel, subfamily V, member 1, as…

Ion channel Atrial natriuretic peptide (ANP)hypertrophy Therapeutic Heart Failure Sildenafil Subfamily V

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