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Research Article 2022-07-17CC BY-NCFree full text · non-commercial reuse

Differential symptoms among COVID-19 outpatients before and during periods of SARS-CoV-2 Omicron variant dominance in Blantyre, Malawi: a prospective observational study

Marah G. Chibwana, Herbert W. Thole, Cat Anscombe, Philip M. Ashton, Edward Green, Kayla G. Barnes +21 more

BackgroundIt is widely reported that the SARS-CoV-2 Omicron variant has resulted in high number of cases, but relatively low incidence of severe disease and deaths, compared to the pre-Omicron variants of concern. We aim to assess the differences in symptom prevalence between Omicron and pre-Omicron infections in a sub-Saharan African population. MethodsIn this cross-sectional observational study, we collected dat…

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Research Article 2021-03-24CC BYFree full text

Impact of COVID-19 on tuberculosis notifications in Blantyre Malawi: an interrupted time series analysis and qualitative study with healthcare workers

Rebecca Nzawa Soko, Rachael M Burke, Helena RA Feasey, Wakumanya Sibande, Marriott Nliwasa, Marc YR Henrion +8 more

COVID-19 may impact on tuberculosis (TB) diagnosis and care. We analysed a city-wide electronic TB register in Blantyre, Malawi and interviewed TB officers. Malawi had no official "lockdown" but closed schools and borders on 23-March 2020. In interrupted time series analysis, there was an immediate 35.9% reduction in TB notifications (95% CI 22.0 to 47.3%) in April, which recovered to near pre-pandemic numbers by…

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