Cannabidiol and skeletal muscle insulin resistance: translational implications for exercise and rehabilitation medicine.

Gergana Todorova, Tanya Gesheva, Anna Mihaylova

Insulin Resistance (IR) is a central pathophysiological mechanism underlying obesity, type 2 diabetes mellitus, metabolic syndrome, and metabolic dysfunction-associated steatotic liver disease, with significant implications for skeletal muscle function, exercise capacity, and rehabilitation outcomes. Because skeletal muscle represents the primary site of insulin-stimulated glucose disposal, muscle insulin resistan…