The Development of a Simple Liquid Chromatography‐Precursor Ion Scan‐Mass Spectrometry Screening Method for the Detection of Phytocannabinoids in Plant Extracts

Radwa Mahmoud, Deborah Michel, Fatma Elessawy, Randy W. Purves, Robert B. Laprairie, Anas El‐Aneed

ABSTRACTScreening of major cannabinoids in cannabis‐derived extracts is needed when these extracts are applied in pharmacological and biological studies. Precursor ion scan‐mass spectrometry (PIS‐MS) is a viable approach for the detection and screening of major cannabinoids through characteristic MS/MS fragmentation behavior. A PIS‐MS method was developed utilizing electrospray ionization (ESI) operated in the pos…