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Research Article 2024CC BYFree full text

Cannabis combined with oxycodone for pain relief in fibromyalgia pain: a randomized clinical self-titration trial with focus on adverse events.

Cornelis Jan van Dam, Cornelis Kramers, Arnt Schellekens, Marcel Bouvy, Eveline van Dorp, Mikael A Kowal +4 more

Objectives We determined whether adding cannabis to oxycodone for chronic non-cancer pain management could reduce treatment-related adverse effects (AEs) while maintaining effective analgesia. Methods In this open-label study, fibromyalgia patients aged ≥18 years were randomized to receive 5 mg oxycodone tablets (max. four times/day), 150 mg of inhaled cannabis containing 6.3% Δ9-tetrahydrocannabinol and 8% cannab…

Frontiers in Pain Research Europe PMC

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Research Article 2023CC BYFree full text

Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination-the SPIRAL study.

Cornelis Jan van Dam, Monique van Velzen, Cornelis Kramers, Arnt Schellekens, Erik Olofsen, Marieke Niesters +1 more

Background Opioids continue to be widely prescribed for chronic noncancer pain, despite the awareness that opioids provide only short-time pain relief, lead to dose accumulation, have numerous adverse effects, and are difficult to wean. As an alternative, we previously showed advantages of using pharmaceutical-grade cannabis in a population of chronic pain patients with fibromyalgia. It remains unknown whether com…

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