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Research Article 2022-12-03CC BYFree full text

Cardiorenal Effects of Angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers in people underrepresented in trials: analysis of routinely collected data with validation against a target trial

Paris J Baptiste, Angel YS Wong, Anna Schultze, Catherine M Clase, Clémence Leyrat, Elizabeth Williamson +8 more

BackgroundCardiovascular disease (CVD) is a leading cause of death globally. Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB), compared in the ONTARGET trial, each prevent CVD. However, trial populations may not be representative of the general population. MethodsUsing trial replication methods within routine-care data, we explored replicability of the ONTARGET trial. For peo…

medRxiv medRxiv

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Research Article 2021-01-14CC BYFree full text

OpenSAFELY NHS Service Restoration Observatory 1: describing trends and variation in primary care clinical activity for 23.3 million patients in England during the first wave of COVID-19

The OpenSAFELY Collaborative, Helen J Curtis, Brian MacKenna, Richard Croker, Peter Inglesby, Alex J Walker +30 more

BackgroundThe COVID-19 pandemic has disrupted healthcare activity globally. The NHS in England stopped most non-urgent work by March 2020, but later recommended that services should be restored to near-normal levels before winter where possible. The authors are developing the OpenSAFELY NHS Service Restoration Observatory, using data to describe changes in service activity during COVID-19, and reviewing signals fo…

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