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Research Article 2021CC BYFree full text

Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus.

Jon Egaña-Huguet, Miquel Saumell-Esnaola, Svein Achicallende, Edgar Soria-Gomez, Itziar Bonilla-Del Río, Gontzal García del Caño +6 more

The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of pre-synaptic cannabinoid CB1 receptors. As CB1 receptors also mediate LTD at these synapses, both CB1 and TRPV1 mig…

Frontiers in Neuroanatomy Europe PMC

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Research Article 2021CC BYFree full text

Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence.

Irantzu Rico-Barrio, Sara Peñasco, Leire Lekunberri, Maitane Serrano, Jon Egaña-Huguet, Amaia Mimenza +10 more

Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later in life. Remarkably, an enriched environment (EE) in adulthood significantly recovers memory in mice after adolescent BD, and the endocannabinoid, 2-arachydonoyl-glycerol (2-AG), rescues synaptic plasticity and memory impaired in adult rodents upon adolescent EtOH intake. However, the…

Biomedicines Europe PMC

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