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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
3 articles
Newest firstCarbapenem-resistant Acinetobacter baumannii (CRAb) has emerged as a major and often fatal cause of bloodstream infections among hospitalized patients in low- and middle-income countries (LMICs). CRAb outbreaks are hypothesized to arise from reservoirs in the hospital environment, but outbreak investigations in LMICs are seldom able to incorporate whole genome sequencing (WGS) due to resource limitations. We perfo…
Open article record in new tab ↗There is an urgent need to improve our understanding of how new antibiotic resistant organisms emerge and spread. A high-priority resistance threat is the ST258 lineage of carbapenem-resistant Klebsiella pneumoniae. Here, we studied resistance to the last-line drug colistin among ST258 by tracking its evolution across 21 U.S. hospitals over the course of a year. Phylogenetic analysis supported a significant fitnes…
BackgroundAmong patients colonized with carbapenem-resistant Klebsiella pneumoniae (CRKP), only a subset develop clinical infection. While patient characteristics may influence risk for infection, it remains unclear if the genetic background of CRKP strains contributes to this risk. We applied machine learning to quantify the capacity of patient characteristics and microbial genotypes to discriminate infection and…
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