Maintaining IV Patency Throughout Pharmacokinetic Studies Through a Needle‐Free Blood Draw Device

William Naviaux, David Leinweber, Heather Barkholtz

ABSTRACTPharmacokinetic (PK) studies require temporally precise measurements of drug concentrations in biological matrices, most commonly whole blood or plasma. However, repeated venous sampling may increase participant burden and complicate PK‐intensive study designs. Needle‐free blood collection devices that access peripheral intravenous (IV) catheters may provide an alternative approach to repeated venipuncture…