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Research Article 2025CC BYFree full text

Novel substance, same old problems: admissions of psychosis precipitated by hexahydrocannabinol, a widely available semi-synthetic cannabinoid.

Brian O’Mahony, Sarah Lanigan, Níall Lally, Andrew O’Malley, Bobby Smyth, Colm McDonald +1 more

Aims and method To investigate the impact of the widespread availability and use of the semi-synthetic cannabinoid hexahydrocannabinol (HHC) on hospital admissions owing to psychosis. Medical records of patients admitted for psychotic illness to University Hospital Galway were examined to assess HHC or other illicit drug use before admission. Results Of the 214 total admissions for psychotic illness, 28 admissions…

BJPsych Bulletin Europe PMC

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Research Article 2025CC BYFree full text

PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample.

Stefania Tognin, Sandra Vieira, Dominic Oliver, Alexis E. Cullen, Mathew J. Kempton, Paolo Fusar-Poli +99 more

Predicting outcomes in individuals at clinical high risk (CHR) of developing psychosis remains challenging using clinical metrics alone. The PSYSCAN project aimed to enhance predictive value by integrating data across clinical, environmental, neuroimaging, cognitive, and peripheral blood biomarkers. PSYSCAN employed a naturalistic, prospective design across 12 sites (Europe, Australia, Asia, Americas). Assessments…

Schizophrenia Europe PMC

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