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Research Article 2022CC BYFree full text

Appetitive Motivation and Associated Neurobiology Change Differentially across the Life Course of Mouse Offspring Exposed to Peri- and Postnatal High Fat Feeding.

Laura Contu, Christopher J Heath, Cheryl A Hawkes, Javier Diaz-Castro, Julio Ochoa Herrera, Naroa Kajarabille Garcia

Alterations in neural pathways that regulate appetitive motivation may contribute to increased obesity risk in offspring born to mothers fed a high fat (HF) diet. However, current findings on the impact of maternal obesity on motivation in offspring are inconclusive, and there is no information about the long-lasting effects in aged animals. This study examined the longitudinal effect of perinatal and chronic post…

Nutrients Europe PMC

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Research Article 2022CC BYFree full text

α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.

Cheryl A Hawkes, Christopher J Heath, Matthew M Sharp, Dariusz C Górecki, Roxana O Carare

α-Dystrobrevin (α-DB) is a major component of the dystrophin-associated protein complex (DAPC). Knockout (KO) of α-DB in the brain is associated with astrocytic abnormalities and loss of neuronal GABA receptor clustering. Mutations in DAPC proteins are associated with altered dopamine signaling and cognitive and psychiatric disorders, including schizophrenia. This study tested the hypothesis that motivation and as…

Acta Neuropathologica Communications Europe PMC

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