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Research Article 2024CC BYFree full text

Evaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial.

Anastasia Suraev, Danielle McCartney, Nathaniel S Marshall, Christopher Irwin, Ryan Vandrey, Ronald R Grunstein +5 more

Cannabis and its major constituents, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being widely used to treat sleep disturbances. However, THC can cause acute cognitive and psychomotor impairment and there are concerns that driving and workplace safety might be compromised the day after evening use. Here, we examined possible 'next day' impairment following evening administration of a typical medicinal…

Psychopharmacology Europe PMC

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Research Article 2023CC BY-NCFree full text · non-commercial reuse

Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder ('CUPID' study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial.

Isobel Lavender, Danielle McCartney, Nathaniel Marshall, Anastasia Suraev, Chris Irwin, Angela L D'Rozario +6 more

Objective Insomnia is the most prevalent sleep disorder, with few effective pharmacotherapies. Anecdotal reports and recent preclinical research suggest that cannabinol (CBN), a constituent of Cannabis sativa derived from delta-9-tetrahydrocannabinol, could be an effective treatment. Despite this, the isolated effects of CBN on sleep have yet to be systematically studied in humans. Methods The present protocol pap…

BMJ Open PubMed Central Open Access

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