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19172026

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Author: Ben Shattenstein

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Research Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Immune-modulating effects of dietary cannabinoid-receptor 2 agonist beta-caryophyllene and cooling frequency in dairy cows under environmental heat load

Liam Hubner, Priscila dos S. Silva, Yana Butenko, Ben Shattenstein, Yuri Portnick, Tali Dogot +5 more

BackgroundEnvironmental heat load negatively affects productivity, welfare and immune function in livestock. The endocannabinoid system regulates immune function, and activation of the cannabinoid receptor 2 (CB2) has mostly anti-inflammatory effects. We hypothesized that increased cooling frequency and providing a dietary CB2 agonist, β-caryophyllene (BCP), could affect immune function in heat-stressed dairy cows…

Frontiers in Immunology PubMed Central Open Access↗

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