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Research Article 2024-01-04CC BYFree full text

A Healthcare Service Delivery and Epidemiological Model for Investigating Resource Allocation for Health: The Thanzi La Onse Model

Timothy B. Hallett, Tara D. Mangal, Asif U. Tamuri, Nimalan Arinaminpathy, Valentina Cambiano, Martin Chalkley +26 more

BackgroundDecisions need to be made in all healthcare systems about the allocation of available resources with the aim of improving population health. Evidence is needed for these decisions, which can have enormous consequences for population health, especially in lower-income settings. MethodsWe address this need using an individual-based simulation model of healthcare need and service delivery that we have devel…

medRxiv medRxiv

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Research Article 2023-08-02CC BYFree full text

Activation of cannabinoid CB2 receptors by (−)-cannabichromene but not (+)-cannabichromene

Michael Udoh, Marina Santiago, Syed Haneef, Alison Rodger, Charles K. Marlowe, Philip J. Barr +1 more

Introduction Cannabichromene (CBC) is a minor constituent of Cannabis that is a selective cannabinoid CB2 receptor agonist and activator of TRPA1. To date, it has not been shown whether (−)-CBC, (+)-CBC (or both) can mediate these effects. In this study we investigate the activity of the CBC enantiomers at CB1, CB2 and TRPA1 in vitro . Materials and Methods CBC enantiomers were purified from synthetic CBC by chira…

bioRxiv bioRxiv

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