Corrigendum: Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis
Entourage Phytolab, São Paulo, Brazil
Bedrocan Brasil, São Paulo, Brazil
UNICAMP, Campinas, Brazil
Article notes
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Received 2018 Nov 2; Accepted 2018 Nov 20; Collection date 2018.
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Keywords: cannabinoids, cannabidiol (CBD), epilepsy, meta-analysis, refractory epilepsy, phytotherapy
In the original article, there was a mistake in Table 2 as published. The total number of one reference was wrongly included in the calculation of the endpoint efficacy over 70%. Where it reads 83/430, it should be 83/311, therefore 27% (instead of 19%). The corrected Table 2 appears below.
| References | Patients | Reported improvement | >50% | >70% | Mean daily dose (mg/kg/day) |
|---|---|---|---|---|---|
| Total reports | 670 | 399/622 | 216/553 | 83/311 | (2–50 mg/kg) |
| Mean | 100% | 64% | 39% | 27% | 15.0 mg/kg |
| CBD pure (6) | 137 | 37% | 37% | 22% | 22.9 mg/kg |
| CBD pure (7) | 7 | 86% | 71% | 57% | 22 mg/kg |
| CBD pure (8) | 13 | 85% | 70% | 46% | 24.6 mg/kg |
| CBD pure (9) | 18 | 72% | 50% | 22% | 37.7 mg/kg |
| CBD pure (10) | 48 | NR | 42% | NR | 28.2 mg/kg |
| CBD-rich extract (11) | 19 | 84% | 74% | 42% | 7.0 mg/kg |
| CBD-rich extract (12) | 117 | 85% | NR | NR | 4.3 mg/kg |
| CBD-rich extract (28) | 75 | 57% | 33% | NR | NR |
| CBD-rich extract (13) | 74 | 89% | 34% | 18% | <10 mg/kg |
| CBD-rich extract (14) | 43 | 83% | 67% | 42% | 3.2 mg/kg |
| CBD-rich extract (15) | 119 | 49% | 24% | NR | NR |
In the original article, there was a mistake in Table 4 as published. Data from one reference was missing in the calculation of the endpoints mild AE and severe AE. Where it reads 285/663, it should be 308/663, therefore 46% (instead of 43%). Where it reads 64/487, it should be 64/483. The corrected Table 4 appears below.
| References | n | Mild AE | Serious AE | Total AE |
|---|---|---|---|---|
| Total reports | 663 | 308/663 | 64/483 | 326/663 |
| Mean | 100% | 46% | 13% | 49% |
| CBD pure (6) | 137 | 79% | 30% | 128/137 |
| CBD pure (9) | 18 | 67% | 0% | 12/18 |
| CBD pure (8) | 13 | 77% | NR | 10/13 |
| CBD pure (10) | 48 | 58% | NR | 28/48 |
| CBD-rich extract (11) | 19 | 37% | 0% | 7/19 |
| CBD-rich extract (12) | 117 | 30% | 0% | 35/117 |
| CBD-rich extract (28) | 75 | 44% | 13% | 33/75 |
| CBD-rich extract (13) | 74 | 46% | 18% | 34/74 |
| CBD-rich extract (14) | 43 | 37% | 0% | 16/43 |
| CBD-rich extract (15) | 119 | 19% | NR | 23/119 |
In the original article, due to the errors in Tables 2, 4 mentioned above, corrections have been made to the Abstract as well as the Results, paragraphs one, two, three and five:
- “81/223, 36%” changed to “81/175, 46%” in Abstract and Results, paragraph one.
- “p = 0.56” changed to “p = 0.52” in Abstract and Results, paragraph two.
- “97/255, 38%” changed to “122/330, 37%” in Abstract and Results, paragraph two.
- “6.1 mg/kg/day” changed to “6.0 mg/kg/day” in Abstract and Results, paragraph two.
- “27.1 mg/kg/day” changed to “25.3 mg/kg/day” in Abstract and Results, paragraph two.
- “(109/285 vs. 291/346, p < 0.0001) and severe (23/285 vs. 77/346, p < 0.0001)” changed to “(158/216, 76% vs. 148/447, 33%, p < 0.001) and severe (41/155, 26% vs. 23/328, 7%, p < 0.0001)” in Abstract and Results, paragraph five.
- “17.7 mg/kg/day” changed to “15.0 mg/kg/day” in Results, paragraph two.
- “18%” changed to “27%” in Results, paragraph three.
- “83/430” changed to “83/311” in Results, paragraph three.
- “(Table 4)” changed to reference “(11)” in Results, paragraph five.
The aut hors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.