A case of clinical worsening after stereo-electroencephalographic-guided radiofrequency thermocoagulation in a patient with polymicrogyria

Abstract A 35-year-old man reported seizures worsening and postictal psychosis after Radiofrequency-Thermocoagulation (RF-TC). Cannabidiol treatment improved seizure frequency/intensity, resolving the postictal psychosis. We recommend clinicians consider the rare potential of RF-TC to exacerbate seizures in patients with epilepsy. Article type: Case Report Keywords: RF-TC, Radiofrequency thermocoagulation, PwP, Patients with polymicrogyria, EEG, electroencephalography, SEEG, stereo-electroencephalography, EZ, Epileptogenic Zone, FDG-PET, Fluorodeoxyglucose-Positron Emission Tomography, CBD, Cannabidiol, Epilepsy, Stereo-EEG, Radiofrequency thermocoagulation, Post-ictal psychosis, Cannabidiol Authors: Lorenzo Ferri, Roberto Mai, Lidia di Vito, Veronica Menghi,