Effect Compartment Model for the Evaluation of Tolerance to Psychological Highness Following Smoking Marijuana

Abstract The purpose of this study is to evaluate the development of tolerance, using a population modeling approach, in recreational marijuana users after acute pulmonary administration of tetrahydrocannabinol (THC), a primary ingredient in marijuana. A total of 85 subjects in 3 separate studies smoked marijuana cigarettes (dose = 13–49 mg) under controlled conditions. Each study was designed as a randomized, crossover, double‐blind, and placebo‐controlled study. Up to 5 THC plasma samples and corresponding user‐reported psychological highness were pooled for population