Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studies

Abstract Objective: To establish the prevalence of long-term and serious harms of medical cannabis for chronic pain. Design: Systematic review and meta-analysis. Data sources: MEDLINE, EMBASE, PsycINFO and CENTRAL from inception to 1 April 2020. Study selection: Non-randomised studies reporting on harms of medical cannabis or cannabinoids in adults or children living with chronic pain with ≥4 weeks of follow-up. Data extraction and synthesis: A parallel guideline panel provided input on the design and interpretation of the systematic review, including