Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity
Abstract Ghovanloo et al. combined in silico and in vitro approaches to determine the mechanism by which CBD inhibits the skeletal muscle Na+ channel Nav1.4. Their findings suggest that CBD acts directly, by binding inside the Nav1.4 pore, as well as indirectly, by modulating membrane elasticity. Authors: Mohammad-Reza Ghovanloo ⚬, Koushik Choudhury, Tagore S. Bandaru ⚬, Mohamed A. Fouda ⚬, Kaveh Rayani ⚬, Radda Rusinova ⚬, Tejas Phaterpekar, Karen Nelkenbrecher, Abeline R. Watkins, Damon Poburko ⚬, Jenifer Thewalt ⚬, Olaf
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