Delta-9-tetrahydrocannabinol reduces the performance in sensory delayed discrimination tasks. A pharmacological-fMRI study in healthy volunteers

Abstract Tetrahydrocannabinol (THC) induced memory-effects on pain information processing. THC effects were not pain specific as similarly observed in a visual task. In fMRI, THC administration resembled omission of the discrimination task. Article type: Research Article Keywords: Cannabis, Human, Pharm-fMRI, Pain, Clincial pharmacology, Pharmacometrics Authors: Carmen Walter, Bruno G. Oertel, Lisa Felden, Ulrike Nöth, Ralf Deichmann, Jörn Lötsch Affiliations: Institute of Clinical Pharmacology, Goethe – University, Theodor – Stern – Kai 7, 60590, Frankfurt am Main, Germany; Fraunhofer Institute of