Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

Abstract Systemic and intrathecal administration of derivatives of a nonpsychoactive component of marijuana significantly suppresses chronic inflammatory and neuropathic pain, without causing analgesic tolerance, in several rodent models. Authors: Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu, Li Zhang Affiliations: Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, and 2Chemical Biological Research Branch, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892;