Hippocampal CB1 receptors mediate the memory impairing effects of Δ9-tetrahydrocannabinol

Abstract It is firmly established that the hippocampus, a brain region implicated in spatial learning, episodic memory, and consolidation, contains a high concentration of CB1 receptors. Moreover, systemic and intrahippocampal administration of cannabinoid agonists have been shown to impair hippocampal-dependent memory tasks. However, the degree to which CB1 receptors in the hippocampus play a specific functional role in the memory disruptive effects of marijuana or its primary psychoactive constituent Δ9-tetrahydrocannabinol (Δ9-THC) is unknown. The present study was designed to determine