Prognostic and therapeutic implications of PSMD14 in hepatocellular carcinoma: an integrative analysis of transcriptomic and single-cell profiles

Abstract Background: Liver hepatocellular carcinoma (LIHC) represents a common and aggressive malignancy characterized by an unfavorable clinical outcome, highlighting an urgent need to discover reliable prognostic indicators and novel therapeutic targets. The present investigation centers on the JAMM family genes, with a specific emphasis on PSMD14, to delineate their functional contributions in the context of LIHC. Methods: We utilized an integrated analytical framework, incorporating bulk RNA sequencing data from The Cancer Genome Atlas (TCGA) and single-cell RNA sequencing (scRNA-seq) datasets,