Cannabis and Cannabinoid-Related Suspected Adverse Drug Reactions: Global Patterns and Cross-National Analysis Based on VigiBase® Data

Abstract Background and Objectives: Despite increasing global use of cannabis and cannabinoids, comprehensive data on their safety profile remain limited. This study aimed to examine global patterns in pharmacovigilance reports associated with cannabis and cannabinoids, irrespective of regulatory status or context of use. Methods: VigiBase®, the World Health Organisation’s global database of individual case safety reports (ICSRs), was analysed in a retrospective cross-sectional study from 1 January 2020 to 31 December 2024 (data extraction: 19 February 2025). “Cannabis ICSRs” included