Pharmacokinetics of Cannabinoids Delivered by Diverse Routes in Rodents

Abstract Background: The rising popularity of medicinal and recreational use of Cannabis sativa L. has prompted a parallel increase in the number of studies administering the plant and extracts of its constituent compounds to animal models. Typical routes of administration of Cannabis to animals differ from traditional use by humans, reducing the translatability of the results of these studies. Summary: While inhalation and ingestion are the most common routes of cannabinoid delivery in humans, injections (intraperitoneal or subcutaneous) are most