Age and Gender Heterogeneity in Adverse Drug Reactions Associated with Hemp Use: Evidence from the FDA Pharmacovigilance Data in the Last Two Decades

Abstract Background: Hemp-derived products are increasingly used for medical and wellness purposes following legalization, yet systematic safety data remain limited. Objective: We aimed to identify the most common adverse drug reactions associated with hemp use and to evaluate age- and gender-specific differences in risk. Methods: We analyzed adverse event reports submitted to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from 1 January, 2004 to 30 June, 2025. Reporting odds ratios (RORs) with 95% confidence intervals (CIs)