Concomitant use of medical cannabis and drugs associated with risks of interaction in older patients: a longitudinal cohort study

Abstract Background: Cannabinoids interact with multiple drugs, with some interactions having significant clinical effects. Objectives: This study aimed to evaluate amongst older people (i) the trends in the concomitant medical use of cannabis and drugs associated with a risk of significant clinical interaction with cannabinoids (DARSCIC), including those with a narrow therapeutic index (drugs with a narrow therapeutic index; DNTI) such as warfarin, and (ii) the risk of bleeding, drug-related intoxication, thyrotoxicosis and major cardiovascular events. Methods: For objective 1,