Do Chronic Stressors Impact the Association Between Substance Use and Well-Being: Findings from the Midlife in the United States Study

Abstract Background: Substance use is a global public health concern. However, how psychological stressors, such as job discrimination, mediate the association between substance use and holistic well-being is still unclear. Methods: Data were merged from the main and the biomarker projects of waves 2 to 3 of the Midlife in the United States (MIDUS) study. Using structural equation models, we examined whether participants’ (N = 1,729; Mage = 62 ± 10) substance use, assessed by the usage of 10 different