A systematic review of protein post-translational modifications in sepsis

Abstract Background: Sepsis originates from the host’s dysregulated response to pathogens, and its pathophysiological mechanisms are extremely complex. Recent research has found that post-translational modifications (PTMs) can regulate gene transcription without altering the genetic sequence, thereby playing a key role in the occurrence and development of sepsis. Objective: This review aims to systematically categorize the main types of PTMs and elucidate their roles in the pathogenesis of sepsis, thereby providing new perspectives for a deeper understanding of the complex pathophysiological