Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC

Abstract We provide a comprehensive picture of the expression landscape of CDC6 in pan-cancer and its close relationship with the prognosis of cancer patients. We explored the possible reasons for the high expression of CDC6 in a variety of cancers and the possible regulatory mechanisms through epigenetic analysis. The experiments were verified in HCC cell lines. We illustrated the relationship of CDC6 expression in multiple cancers with respect to immune cell infiltration, immunomodulatory genes, and immunotherapy. We constructed a CDC6