Medicinal plants and plant-based traditional medicine: Alternative treatments for depression and their potential mechanisms of action

Abstract Background: Clinical depression is a serious public health issue that affects 4.7 % of the world’s population and can lead to suicide tendencies. Although drug medications are available, only 60 % of the depressed patients respond positively to the treatments, while the rest experience side effects that resulted in the discontinuation of their medication. Thus, there is an urgent need for developing a new anti-depressant with a distinct mode of action and manageable side effects. One of the options