Cannabinoids in the treatment of cancer anorexia and cachexia: Where have we been, where are we going?

Abstract Cachexia–anorexia cancer syndrome remains an unmet clinical need with a dearth of treatment and no standard of care. Acting through the endocannabinoid system, cannabinoids are one potential cancer cachexia treatment. Herein, the potential mechanisms for cannabinoids for cancer cachexia are discussed as are previous and ongoing clinical trials. Article type: Review Article Keywords: Cancer, Cachexia, Cannabinoids, Cytokine, Inflammation, Interleukin Authors: Emily Seymour-Jackson, Barry J.A. Laird, Judith Sayers, Marie Fallon, Tora S. Solheim, Richard Skipworth Affiliations: University of Glasgow Medical